2013, Cilt 26, Sayı 1, Sayfa(lar) 017-020
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A randomized, double-blind comparison of nadifloxacin 1% cream alone and with benzoyl peroxide 5% lotion in the treatment of mild to moderate facial acne vulgaris
Züleyha Yazıcı ÖZGEN1, Oya GÜRBÜZ2
1Department of Dermatology, School of Medicine, Bezmialem University, İstanbul, Turkey
2Department of Dermatology, School of Medicine, Marmara University, istanbul, Turkey
Anahtar Kelimeler: Acne, Nadifloxacin, Benzoyl peroxide

Objective: To compare the efficacy of nadifloxacin alone and with benzoyl peroxide in the treatment of mild to moderate facial acne vulgaris.

Patients and Methods: This double-blind, randomized study was conducted in a total of 93 acne patients, with at least 10 inflammatory lesions, but no more than 3 nodules or cysts on the face. All patients were instructed to apply nadifloxacin 1% cream twice daily and randomized to apply either benzoyl peroxide 5% lotion or its vehicle once daily for 8 weeks.

Results: The mean percent reduction in inflammatory lesions were 22.08% in the nadifloxacin group (n=46) and 53.5% in the nadifloxacin+benzoyl peroxide group (n=47). Five (10.9%) patients in the nadifloxacin group and 18 (38.3%) patients in the nadifloxacin+benzoyl peroxide group achieved a 50% and greater reduction in the inflammatory lesion count.

Conclusion: Both treatment regimens were statistically effective, but a significantly greater reduction of the inflammatory lesions was seen in the nadifloxacin+benzoyl peroxide group. The number of patients who achieved a 50% and greater reduction in inflammatory lesion count was significantly higher in the nadifloxacin+benzoyl peroxide group. Both treatment regimens were well tolerated with mild side effects.


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