To compare the efficacy of nadifloxacin alone and with
benzoyl peroxide in the treatment of mild to moderate facial acne
Patients and Methods: This double-blind, randomized study
was conducted in a total of 93 acne patients, with at least 10
inflammatory lesions, but no more than 3 nodules or cysts on the
face. All patients were instructed to apply nadifloxacin 1% cream
twice daily and randomized to apply either benzoyl peroxide 5%
lotion or its vehicle once daily for 8 weeks.
Results: The mean percent reduction in inflammatory lesions
were 22.08% in the nadifloxacin group (n=46) and 53.5% in the
nadifloxacin+benzoyl peroxide group (n=47). Five (10.9%)
patients in the nadifloxacin group and 18 (38.3%) patients in the
nadifloxacin+benzoyl peroxide group achieved a 50% and greater
reduction in the inflammatory lesion count.
Conclusion: Both treatment regimens were statistically
effective, but a significantly greater reduction of the inflammatory
lesions was seen in the nadifloxacin+benzoyl peroxide group. The
number of patients who achieved a 50% and greater reduction
in inflammatory lesion count was significantly higher in the
nadifloxacin+benzoyl peroxide group. Both treatment regimens
were well tolerated with mild side effects.